Table 3.
Relationship between blood lipid levels and gallstone disease risk in the meta-analysis
| Lipids | Datasets | Present cross-sectional study | Previous studies | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | SMD (95%CI) | P | Datasets | Cases | Controls | SMD (95%CI) | P | І2 | ||
| TC | 3 | 45,392 | 507,875 | 0.148 (0.130, 0.166) | 5.15 × 10−18 | 82 | 185,077 | 2,125,345 | 0.031 (−0.017, 0.079) | 0.201 | 91.2% |
| TG | 3 | 45,392 | 507,875 | 0.209 (0.174, 0.243) | 1.70 × 10−32 | 78 | 183,975 | 2,077,581 | 0.390 (0.302, 0.477) | 2.33 × 10− 18 | 97.6% |
| LDL-C | 2 | 44,885 | 497,442 | 0.136 (0.116, 0.156) | 1.36 × 10−40 | 56 | 181,859 | 2,081,769 | 0.070 (0.015, 0.125) | 0.012 | 91.8% |
| HDL-C | 2 | 44,885 | 497,442 | −0.127 (−0.166, −0.089) | 9.17 × 10−11 | 73 | 185,585 | 2,124,631 | −0.215 (− 0.271, − 0.160) | 2.54 × 10−14 | 94.0% |
| Cases | Controls | OR (95%CI) | P | Datasets | Cases | Controls | OR (95%CI) | P | |||
| High vs Low | |||||||||||
| TC | 3 | 45,392 | 507,875 | 0.754 (0.671, 0.848) | 2.25 × 10−06 | 31 | 181,627 | 2,099,042 | 1.013 (0.929, 1.104) | 0.768 | 72.7% |
| TG | 3 | 45,392 | 507,875 | 0.972 (0.806, 1.172) | 0.764 | 34 | 186,393 | 2,329,707 | 1.214 (1.111, 1.326) | 1.71 × 10−05 | 77.7% |
| LDL-C | 2 | 44,885 | 497,442 | 0.893 (0.842, 0.946) | 1.13 × 10−04 | 19 | 176,698 | 2,056,688 | 1.072 (0.889, 1.292) | 0.702 | 91.1% |
| HDL-C | 2 | 44,885 | 497,442 | 0.710 (0.640, 0.787) | 7.03 × 10−11 | 28 | 184,929 | 2,302,029 | 0.625 (0.552, 0.708) | 1.58 × 10−13 | 85.8% |
| Per unit | |||||||||||
| TC | 3 | 45,392 | 507,875 | 0.895 (0.858, 0.933) | 1.89 × 10−07 | 19 | 5478 | 100,853 | 0.999 (0.989, 1.010) | 0.873 | |
| TG | 3 | 45,392 | 507,875 | 1.050 (1.036, 1.065) | 8.68 × 10−13 | 25 | 6217 | 75,537 | 1.007 (1.002, 1.012) | 0.010 | 91.1% |
| LDL-C | 2 | 44,885 | 497,442 | 1.071 (1.014, 1.131) | 0.014 | 15 | 5158 | 96,975 | 0.996 (0.987, 1.006) | 0.487 | |
| HDL-C | 2 | 44,885 | 497,442 | 0.889 (0.833, 0.949) | 4.32 × 10−04 | 25 | 8209 | 125,966 | 0.978 (0.965, 0.990) | 4.32 × 10−04 | 75.3% |
| Present and previous studies | |||||||||||
| Datasets | Cases | Controls | SMD (95%CI) | P | І2 | Begg-P | Egger-P | ||||
| TC | 85 | 230,469 | 2,633,220 | 0.040 (0.009, 0.071) | 0.012 | 90.9% | 0.144 | 0.004 | |||
| TG | 82 | 229,367 | 2,585,456 | 0.302 (0.251, 0.354) | 1.32 × 10−30 | 97.7% | 0.012 | 0.048 | |||
| LDL-C | 59 | 226,744 | 2,579,211 | 0.059 (0.027, 0.092) | 3.85 × 10−04 | 91.6% | 0.024 | 0.014 | |||
| HDL-C | 76 | 230,470 | 2,622,073 | −0.182 (− 0.217, − 0.147) | 3.67 × 10−24 | 93.9% | 0.427 | 0.133 | |||
| Datasets | Cases | Controls | OR (95%CI) | P | І2 | Begg-P | Egger-P | ||||
| High vs Low | |||||||||||
| TC | 34 | 227,019 | 2,606,917 | 0.974 (0.896, 1.059) | 0.539 | 76.5% | 0.700 | 0.265 | |||
| TG | 37 | 231,785 | 2,837,582 | 1.192 (1.097, 1.295) | 3.47 × 10−05 | 75.8% | 0.381 | 0.001 | |||
| LDL-C | 21 | 221,583 | 2,554,130 | 1.054 (0.912, 1.219) | 0.473 | 93.0% | 0.651 | 0.749 | |||
| HDL-C | 30 | 229,814 | 2,799,471 | 0.636 (0.570, 0.710) | 5.97 × 10−16 | 85.0% | 0.972 | 0.003 | |||
| Per unit | |||||||||||
| TC | 23 | 55,203 | 685,076 | 0.992 (0.981, 1.004) | 0.177 | 84.5% | 0.205 | 0.034 | |||
| TG | 28 | 51,609 | 583,412 | 1.011 (1.006, 1.016) | 5.12 × 10−05 | 96.0% | 0.621 | 0.016 | |||
| LDL-C | 18 | 54,376 | 670,765 | 0.998 (0.987, 1.008) | 0.641 | 82.2% | 0.829 | 0.899 | |||
| HDL-C | 27 | 53,094 | 623,408 | 0.974 (0.961, 0.987) | 6.07 × 10−05 | 76.4% | 0.016 | < 0.001 | |||
SMD standard mean difference, TC total cholesterol, TG triglyceride, LDL low density lipoprotein cholesterol, HDL high density lipoprotein cholesterol