Table 5.

Multiple linear regression for the assessment of OA risk factors on the levels of the three serum biomarkers

Variable	sCOMPa				sHAb				sPIICPc
	Est	SE	t	p-value	Est	SE	t	p-value	Est	SE	t	p-value
(Constant)	−14.73	103.4	0.143	0.8868	35.95	42.51	0.8458	0.3987	695.4	136.2	5.106	< 0.0001
Age (per year)	2.865	1.421	2.017	0.0450	1.773	0.584	3.035	0.0027	−0.622	1.872	0.3323	0.7400
BMI (per 1 kg/m2)	4.191	2.502	1.675	0.0955	− 1.663	1.029	1.616	0.1077	1.228	3.297	0.3725	0.7099
Gender	−30.76	26.32	1.168	0.2440	−4.817	10.83	0.445	0.6569	−62.96	34.69	1.815	0.0710
KL grade	15.08	14.36	1.050	0.2950	2.124	5.907	0.359	0.7195	− 163.5	18.92	8.639	< 0.0001
Resting VAS	0.843	6.409	0.132	0.8955	−2.250	2.636	0.8535	0.3944	0.321	8.445	0.0381	0.9697
Walking VAS	−7.532	5.840	1.290	0.1986	−0.615	2.402	0.2561	0.7981	2.459	7.695	0.3195	0.7496
Previous knee Injury	20.49	24.21	0.846	0.3984	5.480	9.956	0.5504	0.5826	6.553	31.90	0.2054	0.8374
Occupational Risk	78.31	25.64	3.054	0.0026	21.30	10.54	2.020	0.0447	26.83	33.78	0.7941	0.4281
Familial OA	1.902	22.94	0.083	0.9340	−2.966	9.436	0.3144	0.7536	−10.28	30.23	0.3402	0.7341

p-values < 0.05 are consider significant and indicated in bold

^a R² = 0.153, model ANOVA: F = 4.05, p < 0.0001

^b R² = 0.112, model ANOVA: F = 2.84, p < 0.001

^cR² = 0.560, model ANOVA: F = 26.81, p < 0.0001