3. Summary of questionnaires in trials and their scoring.

Questionnaire	Description	Measurement
IRLS (Walters 2003)	Symptom severity scale with a total score of 0 to 40 for 10 questions (rating 0 to 4).	Mild RLS: 0 to 10 Moderate RLS: 11 to 20 Severe RLS: 21 to 30 Very severe RLS: 31 to 40
Clinical Global Impressions ‐ Improvement (National Institute of Mental Health 1976)	Evaluation by clinician regarding improvement of condition.	Rating 1 (very much better) to 7 (very much worse)
SF‐A (Goertelmeyer 1985)	Subscore of questions regarding self rated quality of sleep.	Rating 1 to 5 → transformed into SMD
RLS‐6 satisfaction with sleep (Kohnen 2004)	Question regarding satisfaction with sleep in the past 7 days.	Rating 0 (totally satisfied) to 10 (totally unsatisfied) → transformed into SMD
QoL‐RLS (Kohnen 2002)	Total score of 12 questions investigating health related quality of life in RLS patients (6‐point Likert scale).	0 to 60 (high impairment) → transformed into SMD

IRLS: International RLS Severity Rating Scale; SF‐A: Schlaffragebogen‐A; QoL‐RLS: Restless Legs Syndrome Quality of Life questionnaire