Comparison 1. Levodopa versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change on severity scales	2		Mean Difference (Random, 95% CI)	‐1.34 [‐2.18, ‐0.50]
2 Periodic limb movements in sleep	5		Mean Difference (Random, 95% CI)	‐26.28 [‐30.53, ‐22.02]
3 Total sleep time	4		Mean Difference (Random, 95% CI)	5.86 [‐18.56, 30.28]
4 Number of drop outs due to adverse events	6	218	Odds Ratio (M‐H, Random, 95% CI)	0.73 [0.05, 11.34]
5 CGI‐Improvement	2		Mean Difference (Random, 95% CI)	‐1.26 [‐1.89, ‐0.62]
6 Change in self rated quality of sleep	2		Std. Mean Difference (Random, 95% CI)	0.92 [0.52, 1.33]
7 Change in quality of life	2		Mean Difference (Random, 95% CI)	3.23 [1.64, 4.82]
8 Number of patients experiencing adverse events	4	176	Odds Ratio (M‐H, Random, 95% CI)	2.61 [1.35, 5.04]