Comparison 2. Levodopa versus other dopamine agonists.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change on IRLS	2	422	Mean Difference (IV, Random, 95% CI)	5.25 [2.10, 8.40]
2 Periodic limb movements per time in bed	1	78	Mean Difference (IV, Random, 95% CI)	3.80 [‐1.48, 9.08]
3 Total sleep time	1	22	Mean Difference (IV, Random, 95% CI)	‐76.0 [‐155.82, 3.82]
4 Number of dropouts due to adverse events	3	504	Odds Ratio (M‐H, Random, 95% CI)	0.59 [0.33, 1.04]
5 CGI‐Improvement	1	344	Mean Difference (IV, Random, 95% CI)	0.62 [0.37, 0.87]
6 Change in self rated quality of sleep	1	344	Mean Difference (IV, Random, 95% CI)	0.63 [‐0.09, 1.35]
7 Change in disease specific quality of life	1	314	Mean Difference (IV, Random, 95% CI)	5.54 [2.65, 8.43]
8 Number of patients experiencing adverse events	3	461	Odds Ratio (M‐H, Random, 95% CI)	0.35 [0.05, 2.30]