| 1 Change on IRLS | 2 | 422 | Mean Difference (IV, Random, 95% CI) | 5.25 [2.10, 8.40] | 
| 2 Periodic limb movements per time in bed | 1 | 78 | Mean Difference (IV, Random, 95% CI) | 3.80 [‐1.48, 9.08] | 
| 3 Total sleep time | 1 | 22 | Mean Difference (IV, Random, 95% CI) | ‐76.0 [‐155.82, 3.82] | 
| 4 Number of dropouts due to adverse events | 3 | 504 | Odds Ratio (M‐H, Random, 95% CI) | 0.59 [0.33, 1.04] | 
| 5 CGI‐Improvement | 1 | 344 | Mean Difference (IV, Random, 95% CI) | 0.62 [0.37, 0.87] | 
| 6 Change in self rated quality of sleep | 1 | 344 | Mean Difference (IV, Random, 95% CI) | 0.63 [‐0.09, 1.35] | 
| 7 Change in disease specific quality of life | 1 | 314 | Mean Difference (IV, Random, 95% CI) | 5.54 [2.65, 8.43] | 
| 8 Number of patients experiencing adverse events | 3 | 461 | Odds Ratio (M‐H, Random, 95% CI) | 0.35 [0.05, 2.30] |