| 3.1 Clinical Global Impressions Scale Improvement Item (CGI‐I) |
2 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 3.1.1 No. of responders |
2 |
43 |
Risk Ratio (M‐H, Random, 95% CI) |
0.51 [0.16, 1.67] |
| 3.2 Drop‐out rate due to treatment emergent adverse effects |
5 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 3.2.1 Dropout rate |
5 |
174 |
Risk Ratio (M‐H, Random, 95% CI) |
0.94 [0.85, 1.03] |
| 3.3 Clinically Administered PTSD Scale (CAPS): reduction of PTSD symptoms |
3 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 3.3.1 CAPS: Total score |
3 |
129 |
Mean Difference (IV, Random, 95% CI) |
‐14.10 [‐22.57, ‐5.62] |
| 3.3.2 CAPS subscale: Re‐experiencing/intrusion |
3 |
129 |
Mean Difference (IV, Random, 95% CI) |
‐4.73 [‐7.55, ‐1.90] |
| 3.3.3 CAPS subscale: Avoidance/numbing |
3 |
129 |
Mean Difference (IV, Random, 95% CI) |
‐6.01 [‐13.72, 1.70] |
| 3.3.4 CAPS subscale: Hyperarousal |
3 |
129 |
Mean Difference (IV, Random, 95% CI) |
‐5.14 [‐8.16, ‐2.11] |
| 3.4 Symptom severity: Other measures |
2 |
|
Std. Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 3.4.1 Reduction of PTSD symptoms |
2 |
108 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.55 [‐0.94, ‐0.17] |
| 3.5 Self‐rated scales |
3 |
|
Std. Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 3.5.1 Total score |
3 |
119 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.47 [‐1.06, 0.11] |
| 3.5.2 Self‐rated subscale: Re‐experiencing/Intrusion |
1 |
15 |
Std. Mean Difference (IV, Random, 95% CI) |
0.51 [‐0.58, 1.61] |
| 3.5.3 Self‐rated subscale: Avoidance/numbing |
1 |
15 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.30 [‐1.38, 0.78] |
| 3.5.4 Self‐rated subscale: Hyperarousal |
1 |
15 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.06 [‐1.13, 1.01] |
| 3.6 Depression Scale (typically Hamilton Depression) |
2 |
|
Std. Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 3.6.1 Reduction of depression symptoms |
2 |
108 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.62 [‐1.01, ‐0.23] |
| 3.7 Anxiety ‐ Hamilton Anxiety Scale |
1 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 3.7.1 Reduction of anxiety symptoms |
1 |
80 |
Mean Difference (IV, Random, 95% CI) |
‐3.03 [‐6.21, 0.15] |
| 3.8 Sheehan Disability Scale |
2 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 3.8.1 Reduction of functional disability |
2 |
43 |
Mean Difference (IV, Random, 95% CI) |
‐6.57 [‐14.74, 1.61] |
| 3.9 Drop‐out rate due to any cause |
4 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 3.9.1 Dropout rate |
4 |
133 |
Risk Ratio (M‐H, Random, 95% CI) |
0.79 [0.54, 1.14] |
