Inhibition of sEH by TPPU alleviated apoptosis of neurocyte in Aβ-induced AD mice. (A) Representative immunohistochemistry images for apoptosis of neurocyte in the hippocampus assayed by TUNEL. (B) Inhibition of sEH by TPPU suppressed p53 signaling pathway involved in Bcl-2, Bax, cleaved-caspase 3, caspase 3, cleaved-caspase 9, caspase 9, and p53. (C) Quantitative data of Bax/Bcl-2, cleaved-caspase 3/caspase 3, cleaved-caspase 9/caspase 9, and p53. Data represent mean ± SEM, n = 3.