TABLE 3.

Pneumococcal bacteremia due to antibiotic-resistant isolates: therapy and outcome

Reference	Date of study	Age of patient	Underlying disorder	MIC (μg/ml) of:		Therapyb	Outcome
				Penicillin	Ceftriaxone
Jackson et al. (75)	1984	12 mo	Otitis media	0.13–0.5		Penicillin G	Developed meningitis
		10 mo	Otitis media	0.13–0.5		Erythromycin-sulfisoxazole	Good
Schwartz et al. (129)	1991	9 mo	Otitis media	1.25		Ceftriaxone (2 doses), amox/clavc	Improved
		22 mo	Otitis media	0.125		Cefotaxime	Improved
Tan et al. (136)	1992	6 mo	Periorbital cellulitis	0.13		Cefuroxime (3)	Goodd
		11 mo	Periorbital cellulitis	0.13		Cefuroxime (3), penicillin VK (7)	Goodd
		11 mo	None	0.25		Amox/clav (10)	Good
		6 mo	None	0.25		Ceftriaxone (1 dose), amox/clav (10)	Goodd
		6 mo	Buccal cellulitis	0.13		Ceftriaxone (1 dose), amox/clav (10)	Goodd
		85 mo	HIV infection, premature	0.13		Cefuroxime (7) then oral cefuroxime (14)	Goodd
		18 mo	Otitis media	0.25		Penicillin G (3), amox/clav (10)	Goodd
		14 mo	None	0.25		Amox/clav (10)	Good
		18 mo	None	0.13		Ceftriaxone (1 dose), amoxicillin (10)	Goodd
Leggiadro et al. (85)	1994	14 mo	NSa	8	4	Vancomycin	Curative
		14 mo	Cellulitis	4	1	Cefotaxime	Curative
		13 mo	Otitis media, sinusitis	4	4	Cefotaxime, oral erythromycin	Curative
Pikis et al. (117)	1995	16 mo	NS	0.13		Ceftriaxone (1 dose)	Goodd
		15 mo	Otitis media	0.19		Amoxicillin (10)	Goodd
		14 mo	NS	0.5		Ceftriaxone (2 doses)	Goodd
		5 mo	Otitis media	2.0		Cefuroxime (7)	Good
Chesney et al. (33)	1995	16 mo	Sickle cell anemia	2.0	1	Ceftriaxone, vancomycin	Died 36 h later; blood culture negative at 8 h
		30 mo	Sickle cell anemia	0.12		NS	Good
		15 yr	Sickle cell anemia, renal transplant	0.12	0.25	NS	Good

^aNS, not stated. 

^bDays of treatment given in parentheses. 

^cAmox/clav, amoxicillin-clavulanate. 

^dRepeat blood culture negative.