TABLE 4.
Miscellaneous infections reported due to S. pneumoniae nonsusceptible to penicillin
| Reference | Age of patient | Underlying illness | Infection syndrome | Penicillin MIC (μg/ml) | Therapyb | Outcome |
|---|---|---|---|---|---|---|
| Jackson et al. (75) | 8 mo | NSa | Septic arthritis | Intermediate | Cefamandole and aminocillin; completed with oral chloramphenicol | Good |
| Tan et al. (136) | 43 mo | Nephrotic syndrome | Peritonitis | 0.125 | Ampicillin i.v.c for 7 days | Good, afebrile within 24 h |
| 19 mo | Varicella | Septic arthritis | 1.0 | Nafcillin (4), penicillin (7) | Good | |
| Cefotaxime (9), amoxicillin-clavulanate (10) | Afebrile after 8 days | |||||
| Leggiadro et al. (85) | 24 mo | NS | Orbital cellulitis and sinusitis | 8.0 | Vancomycin and cefotaxime; oral clindamycin and rifampin | Curative |
| Pikis et al. (117) | 10 mo | NS | Septic arthritis | 4.0 | Oxacillin (3), cefotaxime (3), vancomycin (21) | Good |
| 3 mo | NS | Osteomyelitis | 0.5 | Oxacillin (3), cefotaxime (3), cefuroxime (8), cephalexin (21) | Good | |
| Gelfand and Cleveland (64) | 71 yr | None | Vertebral osteomyelitis | 0.25 | Ceftriaxone (28) | Good |
| Daum et al. (39) | 4 yr | Choroid plexus carcinoma, bone marrow transplant | Epiglottitis | 2.0 | Vancomycin, ceftazidime | Good |
| Abbasi et al. (1) | 20 mo | None | Septic arthritis and osteomyelitis | 0.38 | Nafcillin (4), vancomycin (2) | Good, afebrile after 24 h |
| Cefotaxime (2), penicillin G (10) | ||||||
| 14 mo | None | Septic arthritis | 1.5 | Nafcillin (7), ceftriaxone (31) | Good, afebrile after 72 h | |
| Vancomycin (28) | ||||||
| 24 mo | None | Septic arthritis | 8.0 | Cefotaxime (6), nafcillin (3), vancomycin (19), rifampin (19), clindamycin (6) | Febrile for 21 days |
a
NS, not stated.
b
Days of treatment given in parentheses.
c
i.v., intravenous.