TABLE 6.
Outcome of treatment for otitis media due to S. pneumoniae: effect of penicillin susceptibility
| Location (reference) | Antibiotics | Dose mg/kg/day | No. of patients with successful clinical outcome/total no. infected
|
||
|---|---|---|---|---|---|
| Penicillin susceptible | Penicillin intermediate | Penicillin resistant | |||
| France (63) | Cefuroxime axetil | 30 | 39/42 | 9/10 | 24/32 |
| Kentucky (23) | Ceftriaxone | 3/5 | 5/6 | ||
| Amoxicillin-clavulanate | 8/10 | 2/2 | |||
| Clindamycin | 2/3 | 2/4 | |||
| Cefixime | 1/5 | 0/3 | |||
| Cefpodoxime | 1/3 | 2/5 | |||
| Cefaclor | 1/2 | 1/4 | |||
| United States (multicenter) (74) | Amoxicillin-clavulanate | 40 and 10 | 56/63 | 7/8 | 7/9 |
| Israel (36, 37)a | Cefuroxime axetil | 30 | 20/22 | 15/19 | |
| Cefaclor | 40 | 24/25 | 5/12 | ||
| Amoxicillin | 50 | 10/10 | 10/14 | ||
| Cefaclor | 40 | 13/16 | 6/17 | ||
| United States (multicenter) (115) | Cefprozil | 40 | 39/50 | 11/12 | 21/31 |
a
Bacteriological cure on day 4 to 5 of therapy by second tympanocentesis culture.