TABLE 3.

Ability of three PspAs to elicit protection against 14 diverse S. pneumoniae challenge strains^a

Strain	Pneumococcal challenge		% of mice alive 21 days after challenge of mice immunized withb:
	Capsule type	PspA type	D39	WU2	BG9739	Nonec
D39	2	25	38	60		3
WU2	3	1	100	100	100	2
A66	3	13	75	100	80	5
EF10197	3	18	100		80	0
ATCC 6303	3	7	100			0
BG9739	4	26	11	60	13	0
EF3296	4	20	25	20	10	0
EF5668	4	12	22	25	60	9
L81905	4	23	10	0	31	0
DBL5	5	33	10		14	0
EF6796	6A	1	100			0
DBL6A	6A	19	67	25	33	4
BG9163	6B	21	89			20
BG7322	6B	24	100	60	25	6

^aImmunized and control CBA/N mice (groups of 10 to 50 animals) were challenged with ∼100 LD₅₀ of each strain. 

^bWhere no data are shown, no experiment was conducted. The results of the same studies have been previously presented as median days alive after challenge (26). Underlined numbers are statistically different from those in the right-hand column (P < 0.05). 

^c“None” includes unimmunized mice and mice immunized with mock preparations from S. pneumoniae lacking the pspA gene.