Table 1.

Comparison of Demographic and Pre-ligation Clinical Characteristics of the Groups

	Group A (≥3 Medical Treatment Cycles), n = 10	Group B (≤2 Medical Treatment Cycles), n = 14	P
Female gender, n (%)	5 (50)	6 (42.9)	.729	χ2
Gestational weeks (week), median (min–max)	26 (24-30)	27 (23-30)	.722	U
Birth weight (g), mean ± SD	847 ± 161	985 ± 193	.079	T
Delivery room resuscitation need, n (%)	9 (90)	8 (57)	.081	χ2
Presence of antenatal corticosteroid use, n (%)	5 (50)	10 (71.4)	.285	χ2
Surfactant dose number, median (min–max)	2 (1-3)	2 (1-4)	.825	U
Day of PDA diagnosis (day), median (min–max)	5.5 (3-10)	6 (3-14)	.721	U
Pre-ligation invasive MV duration (day), median (min–max)	29.5 (14-40)	17 (13-24)	.001	U
Pre-ligation NEC, n (%)				χ2
No	5 (50)	9 (64.3)	.332
Stage 1	1 (10)	3 (21.4)
≥Stage 2	4 (40)	2 (14.3)
Pre-ligation IVH, n (%)				χ2
No IVH	5 (50)	5 (35.7)
Stage 1	3 (30)	6 (42.9)	.712
Stage 2	2 (20)	2 (14.3)
Stage 3	0	1 (7.1)
Pre-ligation ARF, n (%)	2 (20)	1 (7.1)	.348	χ2
Pre-ligation Sepsis, n (%)	5 (50)	4 (28.6)	.285	χ2
Pre-ligation Pulmonary Hemorrhage, n (%)	1 (10)	1 (7.1)	.803	χ2
PDA diameter (mm), median (min–max)	2.9 (1.6-4)	2.7 (2.1- 4)	.860	U
LA/Ao ratio	1.50 ± 0.05	1.48 ± 0.07	.506	t
Ligation day, Median (min–max)	36.5 (21-56)	17 (13-35)	<.001	U

PDA, patent ductus arteriosus; MV, mechanical ventilation; NEC, necrotizing enterocolitis; IVH, intraventricular hemorrhage; ARF, acute renal failure; LA/Ao, left atrium aortic root ratio; χ ² , chi-square test; t, independent samples t test; U, Mann–Whitney U-test.