Table 5.
Sensitivity analysis: functional outcomes and SICH by the TyG index on continuous scale (per unit) and different stroke severities.
| Models | N | Events (%) | Age, sex- adjusted of TyG index | Multivariable- adjusted† of TyG index | ||
|---|---|---|---|---|---|---|
| Variable | OR (95% CI) | p-value | OR (95% CI) | p-value | ||
| Mild severity (NIHSS of 4–8) | ||||||
| Unfavorable functional outcomes at 90 days | 211 | 44.1% (93/211) | 0.99 (0.62–1.59) | 0.9709 | 1.04 (0.64–1.69) | 0.8850 |
| Mortality at 90 days | 211 | 3.3% (7/211) | 0.99 (0.23–4.30) | 0.9912 | 1.35 (0.32–5.62) | 0.6807 |
| SICH at 24–36 h by NINDS | 250 | 2.4% (6/250) | 1.06 (0.32–3.55) | 0.9290 | 1.23 (0.34–4.39) | 0.7547 |
| SICH at 24–36 h by ECASS II | 250 | 0.8% (2/250) | 2.54 (0.48–13.58) | 0.2763 | 2.52 (0.42–15.19) | 0.3144 |
| SICH at 24–36 h by SITS-MOST | 250 | 0.4% (1/250) | 3.80 (0.19–76.59) | 0.3838 | 1.00 (0.10–∞)a | 0.5000 |
| Moderate severity (NIHSS of 9–15) | ||||||
| Unfavorable functional outcomes at 90 days | 286 | 69.6% (199/286) | 1.38 (0.85–2.25) | 0.1983 | 1.43 (0.87–2.36) | 0.1575 |
| Mortality at 90 days | 286 | 4.2% (12/286) | 0.46 (0.17–1.25) | 0.1285 | 0.50 (0.18–1.40) | 0.1877 |
| SICH at 24–36 h by NINDS | 318 | 3.8% (12/318) | 0.79 (0.28–2.19) | 0.4217 | 0.96 (0.31–2.99) | 0.9491 |
| SICH at 24–36 h by ECASS II | 318 | 2.8% (9/318) | 0.79 (0.27–2.32) | 0.6705 | 0.95 (0.28–3.18) | 0.9280 |
| SICH at 24–36 h by SITS-MOST | 318 | 0.6% (2/318) | 2.06 (0.24–17.59) | 0.5091 | 8.99 (0.22–376.14) | 0.2491 |
| High severity (NIHSS of ≥16) | ||||||
| Unfavorable functional outcomes at 90 days | 316 | 83.5% (264/316) | 1.77 (1.02–3.07) | 0.0431* | 1.88 (1.07–3.33) | 0.0295* |
| Mortality at 90 days | 316 | 15.8% (50/316) | 1.42 (0.88–2.29) | 0.1481 | 1.40 (0.86–2.29) | 0.1713 |
| SICH at 24–36 h by NINDS | 346 | 8.4% (29/346) | 0.99 (0.56–1.77) | 0.9736 | 0.97 (0.54–1.74) | 0.9041 |
| SICH at 24–36 h by ECASS II | 346 | 4.3% (15/346) | 1.22 (0.56–2.65) | 0.6120 | 1.19 (0.55–2.54) | 0.6593 |
| SICH at 24–36 h by SITS-MOST | 346 | 2.6% (9/346) | 0.95 (0.34–2.71) | 0.9302 | 0.94 (0.33–2.62) | 0.9006 |
NINDS, National Institute of Neurological Disorders and Stroke; OR, odds ratio; SITS-MOST, Safe Implementation of Thrombolysis in Stroke-Monitoring Study.
*
Statistically significant at p < 0.05.
†
The multivariate logistic regression analysis was adjusted for age, sex, hypertension, and atrial fibrillation.
a
Exact logistic regression model was used.