TABLE 3.

hsp-specific immune responses that confer protection against infection

Pathogen	Protective immune responses against hsp in microbial infection	Reference
Helicobacter pylori	Vaccination with GroES and GroEL homolog of H. pylori protects mice against infection and gastroduodenal disease	78
Histoplasma capsulatum	Vaccination with hsp70 of H. capsulatum enhances host resistance against infection	94
	Vaccination with hsp60 of H. capsulatum protects mice against pulmonary histoplasmosis	95
Mycobacterium tuberculosis	Vaccination with transgenic cell line expressing mycobacterial hsp60 protects mice against infection with M. tuberculosis	262
	Adoptive transfer of αβ T cells or γδ T cells specific for mycobacterial hsp60 confers protection against infection with M. tuberculosis	263
	Treatment of mice with DNA encoding the mycobacterial hsp60 protects mice against M. tuberculosis infection	179
	Treatment of mice with DNA encoding the mycobacterial hsp70 protects mice against M. tuberculosis infection	178
Mycobacterium bovis BCG	Adoptive transfer of CD8 T cells specific for mycobacterial hsp60 confers partial protection against M. bovis infection in mice	310
Plasmodium yoelii	Adoptive transfer of γδ T cells specific for hsp60 of P. yoelii confers partial protection against infection with P. yoelii in mice	289
Yersinia enterocolitica	Adoptive transfer of Yersinia hsp60-reactive CD4 αβ T cells mediates protection against lethal infection with Y. enterocolitica in mice	206
	Immunization of mice with Yersinia hsp60 induces protection against Y. enterocolitica	207