TABLE 4.
hsp involvement in experimentally induced autoimmune diseases
| Disease | Strain | Causative agent | Evidence for hsp60 involvement in disease | Major reference(s) |
|---|---|---|---|---|
| IDDM | NOD mice | Spontaneous | Transfer of CD4 T cells specific for mycobacterial hsp60 accelerates the onset of IDDM | 66 |
| Epitope shared by mycobacterial and mammalian hsp60 is recognized by CD4 T cells causing insulitis | 68 | |||
| Immunization with an hsp60 peptide confers protection | 65, 67, 68 | |||
| Immune response to hsp60 correlates with insulitis | 258 | |||
| Tolerance induced to a self-hsp60 epitope in NOD mice carrying a self-hsp60 transgene | 23 | |||
| AA | Lewis rats | Heat-killed M. tuberculosis | Isolation of an arthritogenic T-cell clone with specificity for a nonconserved mycobacterial hsp60 peptide | 293 |
| Protection is induced by immunization with an hsp60 peptide | 305 | |||
| Protection against AA is induced by vaccination with hsp60-expressing vaccinia virus | 177 | |||
| Protection against AA is induced by immunization with a mycobacterial hsp60 peptide cross-reactive to self-hsp60 | 8 | |||
| Administration of the mycobacterial hsp10 delays onset and severity of disease | 226 | |||
| Protection against AA is induced by immunization with naked DNA encoding mycobacterial hsp60 | 225 | |||
| Intranasal tolerization to an hsp60 peptide suppresses the onset of AA | 222 | |||
| Protection is induced by immunization with mycobacterial hsp70 | 157 | |||
| Pristane arthritis | Mice | Pristane | Immunization with mycobacterial hsp60 confers protection | 287 |
| Induction of disease depends on CD4 T cells specific for hsp60 | 270 | |||
| Self hsp60 is a target for serum antibodies and T cells | 16 | |||
| Self-hsp60 expression is found in inflamed joints | 15 | |||
| Streptococcal cell wall-induced arthritis | Lewis rats | Cell walls of streptococci | Immunization with mycobacterial hsp60 confers protection against disease | 291 |
| Collagen-induced arthritis | Lewis rats | Collagen type II | Immunization with mycobacterial hsp60 slightly suppresses disease | 22 |
| Experimental autoimmune encephalomyelitis | Lewis rats | Myelin basic protein | Immunization with a peptide of the myelin protein cross-reactive with a mycobacterial hsp60 peptide protects against disease | 26 |