TABLE 5.

hsp involvement in human autoimmune diseases

Disease	hsp-specific responses	Reference(s)
RA	Antibodies specific for mycobacterial hsp60	188
	Binding of hsp60-specific antibodies to synovial tissue of patients with RA	55
	Raised expression of self-hsp60 in inflamed synovium in juvenile chronic RA	30
	Response of cross-reactive αβ T cells from inflamed sites to mycobacterial hsp60 and human hsp60	173
	Cross-reactive αβ T cells from synovial fluid of patients with juvenile chronic RA specific for conserved regions of the mycobacterial and human hsp60	56, 112
	T- and B-cell responses to mycobacterial hsp60 in juvenile RA	50
	γδ T cells in synovial fluid of RA reactive for mycobacterial hsp60	121
	Response of cross-reactive γδ T cell clone from synovial fluid to mycobacterial and human hsp60	104
	Overexpression of hsp60 on synovial fluid lymphocytes from RA patients	245
	Localization of mycobacterial hsp60-reactive B cells within affected joints	240
	Correlation of T-cell responses to human hsp60 in early course of oligoarticular RA with disease remission	223
	T cells of synovial fluid and peripheral blood reactive for mycobacterial hsp60	40
SLE	Overexpression of hsp90 in B and T cells of SLE patients	72
	Raised antibody levels to hsp90 in a significant group of SLE patients	44
	Antibodies reactive with hsp90 in childhood-onset SLE	45
MS	hsp70-specific antibodies in serum and cerebrospinal fluid of MS patients	24
	Detection of hsp70-reactive and hsp60-reactive αβ T cells in spinal fluid of MS patients	25, 242
	Correlation of overexpression of hsp60 by immature oligodendrocytes with localization of γδ T cells	256
	Accumulation of γδ T cells in areas of demyelination	256
	Detection of γδ T cells in acute lesions of MS	303
	Induction of hsp expression in oligodendrocytes in vitro	86
	T cells specific for the small hsp, alpha B-crystallin, in MS patients	294
	Increased expression of alpha B-crystallin in astrocytes and oligodendrocytes in MS patients	294
	Increased expression of alpha B-crystallin in early stage of lesional development in a subpopulation of oligodendrocytes	14
Reactive arthritis	Response of αβ T cells from synovial fluid to human hsp60, to stressed host cells, and to mononuclear cells isolated from inflamed joints	112
	Selective stimulation of γδ T cells by in vitro stimulation with hsp60	113
	Recognition of HLA-B27-restricted chlamydial hsp60 peptide by CD8 T cells derived from synovial fluid of patient with chlamydia-induced reactive arthritis	184
	Identification of a T-cell epitope within the chlamydial hsp60 recognized by a T-cell clone isolated from a patient with reactive arthritis	52
Kawasaki disease	Antibodies to mycobacterial hsp60 and autoantibodies to epitopes of human hsp60-specific antibodies	307
Behcet’s disease	hsp60-specific antibodies in serum from patients	170
	T-cell response to self-hsp60	217
	Stimulation of T cells from patients with Behcet’s disease by self hsp60 peptides	138
	γδ T cells of patients reactive to mycobacterial hsp60 peptides	109
Psoriasis	Antibodies specific for mycobacterial hsp60	229
Atherosclerosis	hsp60-specific antibodies	304
	Correlation of intensity of hsp60 expression with recruitment of hsp-reactive T cells	159
	Lysis of macrophages expressing hsp60 from patients by antibodies against self-hsp60	247
Systemic sclerosis	Antibodies specific for mycobacterial hsp60	50
Chronic gastritis	Colocalization of γδ T cells with hsp60 expression of inflammatory gastritis epithelium	71
Hashimoto’s thyroiditis	High expression of self-hsp60 in follicular cells from patients	162