TABLE 6.

Findings militating against a role of hsp in autoimmune diseases

Disease	Finding	Reference(s)
IDDM in NOD mice	GAD is the major disease-inducing antigen	140, 288
	Levels of anti-self-hsp60 antibodies do not exceed levels in control mice	183
Reactive arthritis	The frequency of hsp60-reactive T cells is low in patients with reactive arthritis	175
	In inflammatory synovitis, no response to self-hsp60 of synovial fluid cells is observed	220
RA	Synovial-fluid-derived T cells do not respond to hsp60 in adults with chronic RA	56
	Inconsistent levels of self-hsp-reactive antibodies are found in patients with RA	130
	Similar T-cell responses of synovial fluid and peripheral samples from patients and normal individuals are found with respect to hsp60 reactivity	81
SLE	No evidence is found for increased anti-self-hsp antibody levels	156
	An inconsistent pattern of elevated IgM antibody levels to hsp60 is found in SLE patients	212
MS	hsp60 expression is absent in MS lesions	14