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. 2022 Mar 1;11(1):730–740. doi: 10.1080/22221751.2022.2043727

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Conserved Sequence & MHC-I HLA Analysis of Peptide 2. (A) The sequence of Peptide 2 was highly conserved in the 11 virus variants that have been identified as the variants of interest and the variants of concern, as published by WHO. (B) Position of Peptide 2 (yellow marked segment) in the stereoscopic structure of the spike protein. (C) The global distribution of HLA alleles. (D) Analysis of Peptide 2 by integration of MHC-I binding prediction, MHC-I immunogenicity, and MHC-NP prediction from the HLA alleles.