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. 2022 Feb 25;27(1):45–52. doi: 10.1080/13510002.2022.2046423

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — mROS levels affect stem cell function and fate. The level of mROS is closely related to the fate and function of stem cells. Stem cells maintain basic ROS levels to balance self-renewal and differentiation. When mROS levels are below the baseline, stem cell function is impaired and metabolic capacity is reduced. When mROS accumulate to an intermediate level, loss of immobility and the induction of senescence occur. Further accumulation of mROS to a high level leads to cell death. mROS, mitochondrial reactive oxygen species.