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. 2022 Feb 27;60(1):535–542. doi: 10.1080/13880209.2022.2042327

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — The protective effect of SenA on IL-1β-stimulated chondrocytes. (A) SenA inhibited the expression of catabolic marker proteins (MMP13, ADAMTS4/5) in IL-1β-stimulated chondrocytes. (B) SenA enhanced the expression of anabolic marker proteins (IGF-1, aggrecan and Col2a1) in IL-1β-stimulated chondrocytes. (C) SenA promoted cell proliferation of IL-1β-stimulated chondrocytes. (D) SenA inhibited cell apoptosis of IL-1β-stimulated chondrocytes. *p < 0.05 compared with control (con) group; ^#p < 0.05 compared with IL-1β group.