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. 2022 Mar 2;17(3):e0264312. doi: 10.1371/journal.pone.0264312

Table 2. Clusters, symptom loadings and internal consistency (Cronbach’s ɑ) resulting from principal component analyses.

CKD non-KRT Peritoneal dialysis Haemodialysis Transplant
Symptom clusters Lack of energy & mobility GI Mental health Lack of energy & mobility GI Skin Mental health Lack of energy & mobility GI Skin Lack of energy & mobility GI Skin
Individual symptoms
Pain 0.52 0.62 0.66 0.72
Shortness of breath 0.82 0.61 0.75
Weakness 0.69 0.75 0.82 0.74
Nausea 0.80 0.78 0.85 0.88
Vomiting 0.95 0.83 0.94 0.98
Poor appetite 0.61 0.53 0.65
Constipation 0.58 - - - -
Sore/dry mouth 0.51 0.62
Drowsiness 0.74 0.73 0.70 0.79
Poor mobility 0.84 0.76 0.86 0.96
Itching 0.83 0.83 0.84
Difficulty sleeping 0.59
Restless legs - - - - 0.63
Changes in skin 0.74 0.71 0.78
Diarrhoea 0.61 0.75 0.55 0.61
Feeling anxious 0.89 0.76 0.59 0.55
Feeling depressed 0.79 0.61 0.60 0.55
Cronbach’s α 0.82 0.72 0.76 0.74 0.85 0.56 0.74 0.85 0.73 0.71 0.88 0.72 0.54
Variance (%) 44.6 7.5 6.3 40.3 9.2 7.2 10.7 43.9 5.9 7.0 49.3 7.1 6.8

Note. GI, gastrointestinal; CKD non-KRT, people with chronic kidney disease not receiving kidney replacement therapy