Table 4. Association between within-person change in total symptom cluster scores and within-person change in ability to perform usual activities.

	Haemodialysis			Transplant
Symptom clusters	Unadjusted	Partially Adjusted	Fully adjusted	Unadjusted	Partially Adjusted	Fully adjusted
Lack of energy & mobility	1.13 (1.09,1.18)	1.22 (1.16,1.29)	1.23 (1.16,1.31)	1.29 (1.19,1.39)	1.53 (1.37,1.71)	1.50 (1.32,1.71)
Gastrointestinal	1.10 (1.00,1.21)	1.21 (1.07,1.37)	0.95 (0.82,1.1)	1.30 (1.12,1.52)	1.46 (1.22,1.76)	0.95 (0.75,1.2)
Skin	1.12 (1.05,1.19)	1.15 (1.06,1.24)	0.97 (0.89,1.07)	1.13 (0.95,1.35)	1.41 (1.11,1.8)	1.11 (0.81,1.53)

Note. Values are odds ratios (95% confidence intervals), reflecting the odds of having increased problems with performing usual activities per unit increase in the change in total symptom cluster score; Partially adjusted—adjusted for age, sex, ethnicity, Index of Multiple Deprivation (IMD) quintile and time on kidney replacement therapy. Fully adjusted–adjusted for all variables in the partially adjusted model, and additionally for the total scores of all other symptom clusters and scores of any individual symptoms not appearing in any cluster. Different symptoms comprised each cluster per group (underline denotes symptoms appearing in one patient group but not the other): Lack of energy and mobility (8 symptoms in each, Haemodialysis—pain, shortness of breath, weakness, poor appetite, drowsiness, poor mobility, feeling anxious, feeling depressed; Transplant—pain, shortness of breath, weakness, sore/dry mouth, drowsiness, poor mobility, feeling anxious, feeling depressed); Gastrointestinal (Haemodialysis– 3 symptoms–nausea, vomiting, diarrhoea; Transplant– 4 symptoms–nausea, vomiting, poor appetite, diarrhoea), Skin (Haemodialysis– 4 symptoms–itching, difficulty sleeping, restless legs, changes in skin; Transplant—2 symptoms–itching, changes in skin).