TABLE 4.

O⁶-MedG content of DNA from human bladder tissues and from the livers of mice infected with S. mansoni

Type of tissue	O6-MedG concn (μmol/mol of deoxyguanosine)
Human bladder tissues
Egyptian schistosomiasis patients with bladder cancera
Uninvolved tissueb
All	0.171 ± 0.11 [8/8]
Male	0.119 ± 0.07 [4/4]
Female	0.225 ± 0.13 [4/4] (P < 0.15)
Tumor tissues
All	0.126 ± 0.10 [36/38] (P < 0.15)
Male	0.134 ± 0.11 [30/31] (P < 0.15)
Female	0.095 ± 0.07 [6/7] (P < 0.01)
All samples	0.134 ± 0.10 [44/46]
Egyptian uninfected patients with bladder cancerac	0.025 [2/5]
European (U.K.) non-bladder cancera	0.046 ± 0.08 [4/12]
Liver tissues of miced
Control	ND [5]e
Male infected	0.239 ± 0.147 [5]e
Control	ND [2]f
Female infected	0.152 ± 0.11 [2]f

^aMean ± SD value [positive samples/number assayed] of individual samples. Student’s t test was used, and only values of P < 0.15 are represented. Data are from reference 18. 

^bNormal tissue, close to the tumor site, removed at surgery. 

^cData are from references 11 and 11a. 

^dAnimals infected with 300 cercariae/mouse 30 days before sampling. Data are from reference 15. 

^eMean of five experiments in each of which the DNA adduct level was determined from the pooled liver samples of five animals. ND, not detected. 

^fMean of two experiments, otherwise as in footnote e.