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. 2022 Feb 23;2022:5503575. doi: 10.1155/2022/5503575

Figure 6.

Figure 6

String network and IPA pathway analysis of CBX4 activation and knockdown in senescence. (a) STRING analysis of interactions of proteins corresponding to the 37 analyzed and detected genes. Red: genes related to regulation of cell cycle (GO: 0051726, strength: 1.0, FDR: 1.57e-15); green: genes related to regulation of apoptotic process (GO: 0042981, strength: 0.91, FDR: 8.16e-15); purple: genes related to DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO: 0006977, strength: 1.95, FDR: 4.18e-14); yellow: proteins related to replicative senescence (GO: 0090399, strength: 2.31, FDR: 2.15e-08). (b) and (c) CBX4 knockdown (KD, light blue) and activation (ACT, light red) were normalized with the control for the gene expression and analyzed for canonical pathways (b) and compared using biofunction pathway analysis and presented in the heat map ((c), orange: increase; blue: decrease).