Table 1.
Characteristics of HIV-positive individuals with and without SARS-CoV-2 diagnosis in Catalonia, Spain.
| People living with HIV (PLWH) No. (%) |
||||
|---|---|---|---|---|
| All | SARS-CoV-2 negative | SARS-CoV-2 positive | p value | |
| Characteristic | (n = 13,142) | (n = 12,393) | (n = 749) | |
| Sex | ||||
| Male | 10,739 (81.7) | 10,121 (81.7) | 618 (82.5) | 0.59 |
| Female | 2402 (18.3) | 2271 (18.3) | 131 (17.5) | |
| Missing | 1 (0.01) | 1 (0.01) | 0 (0) | |
| Age, median (IQR), y | 47.6 (39.6–54.9) | 47.8 (39.8–55.0) | 43.5 (37.0–52.7) | <0.001 |
| Country of origin | <0.001 | |||
| Spain | 8564 (65.2) | 8162 (65.9) | 402 (53.7) | |
| Outside Spain | 4576 (34.8) | 4229 (34.1) | 347 (46.3) | |
| Unknown | 2 (0.02) | 2 (0.02) | 0 (0) | |
| HIV transmission route | <0.001 | |||
| PWID | 1876 (14.3) | 1817 (14.7) | 59 (7.9) | |
| MSM | 6870 (52.3) | 6425 (51.8) | 445 (59.4) | |
| Male heterosexual | 1768 (13.5) | 1680 (13.6) | 88 (11.8) | |
| Female hetero/homo/bisexual | 1714 (13.0) | 1609 (13.0) | 105 (14.0) | |
| Other | 787 (6.0) | 741 (6.0) | 46 (6.1) | |
| Missing | 127 (1.0) | 121 (1.0) | 6 (0.8) | |
| Years since HIV diagnosis, median (IQR) | 12.0 (7.0–18.7) | 12.1 (7.1–18.9) | 10.3 (6.1–15.7) | <0.001 |
| Recent CD4 count (cells/mm3), median (IQR) | 692.5 (500.0–917.0) | 692.0 (500.0–917.0) | 695.5 (483.5–912.3) | 0.65 |
| CD4/CD8 ratio, median (IQR) | 0.9 (0.6–1.2) | 0.9 (0.6–1.2) | 0.9 (0.6–1.2) | 0.26 |
| HIV-RNA(recent)a | 0.19 | |||
| Detectable | 1068 (8.1) | 1017 (8.2) | 51 (6.8) | |
| Undetectable | 10,758 (81.8) | 10,136 (81.8) | 622 (83.0) | |
| Missing | 1316 (10.0) | 1240 (10.0) | 76 (10.2) | |
| Chronic comorbidities | ||||
| Number of chronic comorbidities | 0.83 | |||
| 0 | 4489 (34.2) | 4231 (34.1) | 258 (34.5) | |
| 1 | 3434 (26.1) | 3247 (26.2) | 187 (25.0) | |
| 2 | 2244 (17.1) | 2106 (17.0) | 138 (18.4) | |
| 3 | 1325 (10.1) | 1253 (10.1) | 72 (9.6) | |
| ≥ 4 | 1650 (12.6) | 1556 (12.6) | 94 (12.6) | |
| Years on ART, median (IQR) | 9.4 (5.1–15.0) | 9.5 (5.1–15.2) | 7.8 (4.6–12.9) | <0.001 |
| Backbone ART | 0.79 | |||
| TAF | 6606 (50.2) | 6215 (50.2) | 391 (52.2) | |
| TDF | 939 (7.2) | 891 (7.2) | 48 (6.4) | |
| ABC + 3TC | 3820 (29.1) | 3594 (29.0) | 226 (30.2) | |
| Other | 670 (5.1) | 630 (5.1) | 40 (5.3) | |
| Missing | 1107 (8.4) | 1063 (8.6) | 44 (5.9) | |
Abbreviations: SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2; IQR, interquartile range; PWID, people who inject drugs; MSM, men who have sex with men; ART, antiretroviral therapy; TAF, tenofovir alafenamide; TDF, tenofovir disoproxil fumarate; ABC, abacavir; 3TC, lamivudine.
a
Undetectable HIV/RNA plasma viral load was defined as values ≤50 copies/ml.