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. 2022 Feb 23;603(7899):119–123. doi: 10.1038/s41586-022-04428-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — a, Confocal cross section through the optic lobe of a fly expressing GFP (green) under control of R39H12-GAL4 (T4/T5 >) as used in behavioural experiments in Fig. 5d–i. Synaptic structures were counterstained with an antibody against bruchpilot (grey). Scale bar, 40 µm. The micrograph is representative of 8 biological replicates. b, Average forward walking speeds of flies expressing GluClα^RNAi (teal) or Nmdar1^RNAi (grey) in T4/T5 neurons and their parental controls (black/grey) during closed-loop bar fixation experiments in Fig. 5h, i. c, Confocal cross section through the optic lobe of a fly expressing GFP (green) under control of the split GAL4 line R59E08-AD; R42F06-DBD. Synaptic structures were counterstained with an antibody against bruchpilot (grey). Scale bar, 40 µm. The micrograph is representative of 5 biological replicates. d, Average forward walking speeds of flies expressing GluClα^RNAi (teal) under control of R59E08-AD; R42F06-DBD and their parental controls (black/grey) during closed-loop bar fixation in e, f. e, Exemplary bar trajectories (242 trials and 11 flies per genotype, top) and the overall bar position probabilities (bottom) for flies expressing GluClα^RNAi (teal) under control of R59E08-AD; R42F06-DBD and their parental controls (back/grey). Data are mean ± s.e.m. of flies in f. f, The percentage of time that the bar occupied a central 60° window (fixation in front, dashed lines in e). The dashed line indicates the chance level. Circles, individual flies; bars, mean ± s.e.m. Asterisk denotes a significant difference from both parental controls (P = 0.0012, one-way ANOVA followed by Holm–Šídák’s multiple comparisons test). n values indicate the number of flies.

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