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. 2022 Feb 23;603(7899):91–94. doi: 10.1038/s41586-022-04446-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a, Virtual thin section (100 μm thick, average-value projection) with osteohistological features indicated. b, Segmented osteocyte lacunar distribution (black dots). c, Osteocyte lacunar density ma 54= Sanchez et al., 2013 p⁵⁴with gradient scale. d, Virtual thick section (100 μm thick, minimum-value projection). e, Three-dimensional osteocyte lacunar distribution at d (depth circa 1230 μm), colour-coded by volume. f, Oscillating osteocyte lacunar volumes towards periosteal margin (10-point moving average) in dashed box in e. Successive annual growth climaxes (green arrows) and growth cessations (LAGs; red arrows) indicated. Typical annual maximum osteocyte lacunar volumes and highest osteocyte lacunar densities were not yet achieved in the year of death, indicating that growth ceased prior to the annual growth climax projected to occur during summer. Because the data resolution (voxel size of 4.35 μm: appropriate for assessing growth marks and osteocyte lacunar distributions) is sixfold lower than that demonstrated in detailed osteocyte lacunar volume reconstructions¹⁸ (voxel size of 0.7 μm), these results should be considered qualitatively.