Table 3:

Univariable and multivariable results of the Cox survival analysis using preselected baseline variables

		Univariable analysis			Multivariable analysis
Variable	n	Hazard Ratio (HR)	95%CI	P value	HR	95%CI	P Value
Age, years	80	1.00	0.98–1.03	0.61
MELD score, per unit	78	1.21	1.12–1.30	<0.0001
MELD-Na, per unit	78	1.16	1.09–1.23	<0.0001	1.13	1.06–1.2	0.0003
CTP score, per unit	78	1.35	1.19–1.54	<0.0001
ALP, IU/L	78	1.00	1.00–1.01	0.03
Albumin, g/dl	78	0.49	0.31–0.78	0.002
Resting heart rate, bpm	79	1.02	1.00–1.04	0.05	1.02	1.00–1.05	0.05
Mean PAP, mmHg	80	1.00	0.98–1.03	0.97
CI (thermo), L.min−1.m2	74	1.03	0.79–1.34	0.81
PVR, Wood units	80	0.94	0.86–1.04	0.24
MvO2, %	64	1.00	0.97–1.03	1.00
RV dysfunction, present	75	0.97	0.57–1.65	0.92
PAH treatment during first 6 months, yes	80	1.07	0.57–2.02	0.84
Hepatic Encephalopathy, present	79	2.90	1.66–5.08	0.0002	2.04	1.09–3.85	0.03
Ascites, present	79	2.09	1.20–3.65	0.009
WHO functional class 1–2 vs. 3–4	77	0.95	0.55–1.62	0.85
Serum sodium, mmol/dl	78	0.91	0.84–0.98	0.02
Total bilirubin, mg/dl	78	1.23	1.06–1.42	0.006
INR	78	2.65	0.83–8.45	0.10
Serum creatinine, mg/dl	78	2.44	1.63–3.67	<0.0001
Etiology of liver disease	80
Alcohol v/s others	15	0.83	0.39–1.72	0.61
NAFLD v/s others	16	0.79	0.38–1.65	0.54
Hepatitis C v/s others	16	0.57	0.27–1.19	0.13

All characteristics at the time of POPH diagnosis unless specified otherwise

Abbreviations: ALP, Alkaline Phosphatase; BMI, Body Mass Index; CTP, Child-Turcotte-Pugh; INR, International Normalized Ratio; LVEF, Left Ventricular Ejection Fraction, NAFLD, Non-alcoholic Fatty Liver Disease, Model for End stage Liver Disease; MELD- Na, Model for End stage Liver Disease with serum sodium; WHO, New York Heart Association;