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. Author manuscript; available in PMC: 2022 Mar 3.
Published in final edited form as: Nat Chem Biol. 2021 Dec 16;18(3):313–320. doi: 10.1038/s41589-021-00914-3

Fig. 6. Properties of E-Syt-mediated ER-PM contacts can be theoretically modeled.

Fig. 6.

(a, c) Schematics of different C2 binding and membrane tethering states of E-Syt1 (a) or E-Syt2 (c) in the absence and presence of Ca2+. (b, d) Calculated probabilities (top panel), tethering force (middle), and total free energy (bottom) of different states of E-Syt1 (b) or E-Syt2 (d). Calculations corresponding to the presence of Ca2+ or the absence of Ca2+ are indicated by solid and dashed lines, respectively. Equilibrium states are indicated by filled circles with their sizes representing the corresponding state probabilities.