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. Author manuscript; available in PMC: 2022 Jun 30.
Published in final edited form as: Nat Chem Biol. 2021 Dec 30;18(3):305–312. doi: 10.1038/s41589-021-00948-7

Extended Data Fig. 9. Alignment of reductase enzymes suggests independent evolution of CerR and KDSR.

Extended Data Fig. 9

(a-b) Alignments of bacterial CerR proteins (a) or C. crescentus CerR and human KDSR (b) were done using Clustal Omega44. Green-highlighted residues are active site amino acids in KDSR34. The YxxxK motif is the reductase active site and the TGxxxGxG motif is the NAD binding site. Note that the bacterial NAD binding site, TGxxGFxG, is different from the eukaryotic site.