Table 1.
Ordinary Least Squares (OLS) Regression and Negative Binomial (NB) Models Predicting Alcohol Use Measures from ACR-P3, Reward P3, and Reward Dysregulation P3 quantified by averaging stimulus-locked EEG activity at P3, Pz, P4, P7, P8, O1, and O2.
| Model | Alcohol Use | Binge Drinking | Max Drinks | Alcohol Problems | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Adj. R2 | AIC | b | SE b | p | Adj. R2 | AIC | b | SE b | p | Adj. R2 | AIC | b | SE b | p | Adj. pseudo-R2 | AIC | b | SE b | p | ||||
| Model 1: ACR-P3 | .10 | 1220.4 | .07 | 624.65 | .06 | 921.91 | 0.15 | 655.58 | |||||||||||||||
| Age | −0.35 | 0.55 | .522 | −0.05 | 0.06 | .385 | −0.22 | 0.19 | .248 | 0.03 | 0.02 | .152 | |||||||||||
| Gender | 11.30 | 3.38 | .001 | 0.53 | 0.39 | .174 | 3.33 | 1.15 | .005 | −0.07 | 0.14 | .603 | |||||||||||
| Race | 10.77 | 5.33 | .046 | 1.16 | 0.60 | .055 | 2.61 | 1.82 | .155 | 0.54 | 0.28 | .023 | |||||||||||
| Alcohol Use/Heavy Drinking | 0.06 | 0.01 | <.001 | ||||||||||||||||||||
| ACR-P3 | 0.41 | 0.39 | .298 | 0.11 | 0.05 | .015 | 0.10 | 0.13 | .456 | 0.04 | 0.02 | <.001 | |||||||||||
| Model 2: Reward-P3 | .10 | 1219.6 | .03 | 630.41 | .08 | 919.47 | 0.14 | 661.45 | |||||||||||||||
| Age | −0.51 | 0.55 | .356 | −0.08 | 0.06 | .235 | −0.27 | 0.19 | .147 | 0.04 | 0.02 | .133 | |||||||||||
| Gender | 9.06 | 3.53 | .011 | 0.28 | 0.41 | .501 | 2.49 | 1.20 | .040 | −0.10 | 0.15 | .516 | |||||||||||
| Race | 12.45 | 5.27 | .020 | 1.45 | 0.60 | .018 | 3.15 | 1.79 | .081 | 0.73 | 0.28 | .010 | |||||||||||
| Alcohol Use/Heavy Drinking | 0.06 | 0.01 | <.001 | ||||||||||||||||||||
| Reward-P3 | −0.59 | 0.43 | .168 | −0.03 | 0.05 | .524 | −0.25 | 0.15 | .088 | 0.01 | 0.02 | .623 | |||||||||||
| Model 3: ACR-P3 + Reward-P3 | .13 | 1216.3 | .11 | 620.08 | .10 | 916.83 | .16 | 654.86 | |||||||||||||||
| Age | −0.45 | 0.54 | .409 | −0.07 | 0.06 | .287 | −0.25 | 0.18 | .173 | 0.03 | 0.02 | .196 | |||||||||||
| Gender | 8.75 | 3.48 | .013 | 0.23 | 0.40 | .568 | 2.39 | 1.18 | .045 | −0.12 | 0.14 | .399 | |||||||||||
| Race | 10.93 | 5.24 | .039 | 1.16 | 0.59 | .049 | 2.67 | 1.78 | .137 | 0.61 | 0.28 | .030 | |||||||||||
| Alcohol Use/Heavy Drinking | 0.06 | 0.01 | <.001 | ||||||||||||||||||||
| ACR-P3 | 1.06 | 0.47 | .025 | 0.19 | 0.05 | <.001 | 0.34 | 0.16 | .036 | 0.06 | 0.02 | <.002 | |||||||||||
| Reward-P3 | −1.25 | 0.51 | .016 | −0.15 | 0.06 | .012 | −0.46 | 0.17 | .009 | −0.04 | 0.02 | .102 | |||||||||||
| Model 4: Reward Dysregulation P3 | .13 | 1214.5 | .11 | 618.69 | .11 | 915.45 | .15 | 655.53 | |||||||||||||||
| Age | −0.42 | 0.53 | .435 | −0.07 | 0.06 | .240 | −0.23 | 0.18 | .201 | 0.03 | 0.02 | .201 | |||||||||||
| Gender | 1.18 | 3.31 | <.006 | 0.14 | 0.38 | .717 | 2.66 | 1.13 | .020 | −0.17 | 0.14 | .238 | |||||||||||
| Race | 10.61 | 5.17 | .042 | 1.23 | 0.58 | .035 | 2.47 | 1.76 | .164 | 0.65 | 0.28 | .020 | |||||||||||
| Alcohol Use/Heavy Drinking | 0.06 | 0.01 | <.001 | ||||||||||||||||||||
| Reward Dysregulation P3 | 1.13 | 0.43 | .009 | 0.17 | 0.05 | <.001 | 0.39 | 0.15 | <.009 | 0.05 | 0.02 | .010 | |||||||||||
| Model 5: ACR-P3-Nonalcohol P3 | .09 | 1221.0 | .04 | 629.41 | .07 | 921.18 | 0.15 | 658.18 | |||||||||||||||
| Age | −0.40 | 0.55 | .470 | −0.07 | 0.06 | .286 | −0.22 | 0.19 | 0.234 | 0.04 | 0.02 | .228 | |||||||||||
| Gender | 10.59 | 3.34 | .002 | 0.34 | 0.39 | .378 | 3.12 | 1.14 | .007 | −0.17 | 0.14 | .252 | |||||||||||
| Race | 11.08 | 5.34 | .040 | 1.30 | 0.61 | .034 | 2.51 | 1.82 | .169 | 0.69 | 0.28 | .016 | |||||||||||
| Alcohol Use/Heavy Drinking | 0.06 | 0.01 | <.001 | ||||||||||||||||||||
| ACR-P3-Nonalcohol P3 | 0.35 | 0.49 | .471 | 0.07 | 0.06 | .242 | 0.19 | 0.17 | .263 | 0.04 | 0.02 | .059 | |||||||||||
Note: Analyses were based on N = 143, except models using alcohol problems as the outcome, which were based on N = 103. ACR-P3 = P3 amplitude elicited by alcohol cues; Reward-P3 = P3 amplitude elicited by natural reward cues; Reward dysregulation P3 = ACR-P3 minus Reward-P3; Alcohol Use = product of typical drinking frequency (number of drinking days/week) and drinking quantity (number of drinks/drinking day) in the past year; Binge Drinking = number of days in the past year in which four or more (women) or five or more (men) drinks were consumed within a 2-hr period; Max Drinks = largest number of drinks consumed within a 24-hr period in the past year; Alcohol Use/Heavy Drinking = composite created by averaging responses to Alcohol Use, Binge Drinking, and Max Drinks measures. Adj. R2 = adjusted proportion of variance explained (McFadden’s adjusted pseudo-R2 for NB models). AIC = Akaike’s Information Criterion; b = unstandardized regression coefficient; SE b = standard error for b. All regression coefficients (and associated SE, test statistics, and p-values) significant at the level of p < .05 are shown in bold.