TABLE 5.

Summary of UTI and Incomplete Emptying rates reported in prior studies of intradetrusor onabotulinumtoxina

Study	Design	Units	Inclusion/exclusion	Incomplete empty definition	IE rate	UTI definition	UTI rate
Brubaker (2008)	RCT	200 units BTA	PVR < 150 ml or SIC	PVR ≥ 200 ml	43%		44%
Dmochowski (2010) 5	RCT	Dose ranging: 50–300 units	PVR < 200 ml 8+ UUI per week and ave 8+ voids per day	PVR > ≥ 200	18% 11% SIC		36%
Visco (2012) 7	RCT	100 units	PVR < 150 ml 5+ UUI in 5 days	PVR ≥ 150 with symptoms; or PVR ≥ 300	Do not give overall #	Not Reported	33%
Nitti (2013) 9	RCT	100 units	PVR < 100 ml 3+ UUI in 3 days and ave 8 voids per day	PVR ≥ 200 with symptoms; or PVR ≥ 350 Retention = PVR ≥ 200 requiring SIC	I.E. = 5.4%; SIC = 6.1%	Positive urine culture	15.5%
Amundsen (2016) 12	RCT	200 units	PVR < 150 ml 6+ UUI in 3 days	PVR ≥ 200 with symptoms; or PVR ≥ 300	20% at any visit	Not Reported	35%
Rahnama’i (2017)15	Retrospective series	Up to 300 Units	Included NGB		De novo CIC rate 24%
Moita (2017)14	Prospective cohort	100 Units	Women with idiopathic OAB		Retention requiring ISC 6% at 2 weeks, 0 at 12 weeks.; PVR > 200 6% @ 2 weeks, 0.4% at 12 weeks	Not Reported	Not Reported
Patel (2018)8	Retrospective series	100 units	Any women undergoing BTX-A injection with ROAB, no PVR limits	<200 200–349 ≥350	1% @ 2 weeks	+UCx with symptoms	36%
Faure Walker (2019)13	Retrospective series	Up to 300 units	Men and women		48.9% de novo CIC in men receiving 100 U; 35.3% in women receiving up to 300 U

Abbreviations: CIC, clean intermittent catheterization; PVR, postvoid residual; RCT, randomized controlled trial; UTI, urinary tract infection; UUI, urgency urinary incontinence epsidodes.