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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Cell Metab. 2022 Feb 4;34(3):355–377. doi: 10.1016/j.cmet.2022.01.007

Figure 1. Deregulated uptake of glucose and amino acids.

Figure 1.

Growth factor stimulation or oncogenic activation triggers the uptake of glucose and amino acids. Solid arrows depict metabolite movement or metabolic reactions. Dashed arrows depict regulatory effects of signal transduction components. RTK, receptor tyrosine kinase; PI3K, phosphoinositide 3-kinase; HK, hexokinase; GLUT1, glucose transporter, also known as SLC2A1; PHGDH, phosphoglycerate dehydrogenase; MCT, monocarboxylate transporter; GLS1, glutaminase, also known as GLS.