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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Cell Metab. 2022 Feb 4;34(3):355–377. doi: 10.1016/j.cmet.2022.01.007

Figure 8. Alterations in metabolite-driven signaling events.

Figure 8.

The availability and abundance of metabolites regulate signaling events and gene expression. Solid arrows depict metabolite movement or metabolic reactions. Dashed arrows depict regulatory effects of signal transduction components. HAT, histone acetyltransferase; Ac, an acetyl mark; Me, a methyl mark; HMT, histone methyltransferase; DNMT, DNA methyltransferase; JHDM, Jumonji domain-containing histone demethylase; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine; TET1/2, ten-eleven translocation methylcytosine dioxygenase 1/2; GEF, guanine nucleotide exchange factor; FTO, fat mass and obesity-associated protein; ALKBH5, alkb homolog 5; METTL3, methyltransferase 3; METTL14, methyltransferase 14; m6A, N6-methyladenosine; α-KG, α-ketoglutarate; 2-HG, 2-hydroxyglutarate.