Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 18;239(3):935–949. doi: 10.1007/s00213-022-06086-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022, corrected publication 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2. — Effects of MDMA on behavioral sensitization. Mice were trained for 7 days and locomotion (a–c), stereotypy (d–f), and verticality (g–i) on the drug-paired side were measured. a, d, g Time course of activity on day 1 (left) and day 7 (right) of training. There were no group differences on day 1, but on day 7, mice receiving 10 mg/kg MDMA exhibited increased locomotion (a), stereotypy (d), and verticality (g) relative to saline controls. b, e, h Average activity on each of the seven days of training. Mice receiving 10 mg/kg MDMA exhibited increased locomotion (b), stereotypy (e), and verticality (h) relative to saline controls from day 3 to day 7. c, f, i Development of sensitization as measured by the difference in average activity on day 7 versus day 1. Mice receiving 10 mg/kg MDMA exhibited a greater increase in locomotion (c), stereotypy (f), and verticality (i) from day 1 to day 7 relative to saline controls. Asterisks identify significant comparisons against the saline control group at the same time point