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. 2022 Feb 17;10:805402. doi: 10.3389/fcell.2022.805402

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Copyright © 2022 Jianfeng, Yutao and Jianbin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overexpression of INMT inhibited cell activity and proliferation and promoted apoptosis. (A) Correlation between INMT and proliferation-related genes (CTNND1, MKI67, PCNA, TOP2A) and apoptosis-related gene. (B) PCNA protein levels were measured using western blotting. (C) Overexpression of INMT suppressed cell viability according to the RTCA assay. (D) The effect of INMT overexpression on cell proliferation was determined using the CCK-8 assay. (E) Bcl-2, caspase 3, and cleaved caspaase3 protein levels were measured using western blotting. (F) Apoptosis was measured using flow cytometry in 22Rv1 and PC-3 cells after INMT overexpression.