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. 2022 Feb 17;13:843558. doi: 10.3389/fimmu.2022.843558

Figure 1.

Figure 1

Proposed mechanisms of microglia-mediated damage in degenerative eye diseases. Activated microglia may provide less robust neurotrophic support and carry out excessive phagocytosis. They may also secrete pro-inflammatory cytokines, which in turn can induce the release of neurotoxins from resident glial cells as well as recruit immune cells from outside of the eye.