TABLE 5.
Association between immune biomarkers and waist circumference in Yup'ik participants
| Adiposity variable (predictor) | β (SE) | P value1 | Empirical P values2 | |
|---|---|---|---|---|
| Proinflammatory Cytokines & Biomarkers (Outcome) | ||||
| hsCRP | WC | 0.0188 (0.0082) | 0.0243 | 0.0093 |
| GM-CSF | WC | –0.0043 (0.0081) | 0.595 | 0.313 |
| IL-6 | WC | 0.0085 (0.0106) | 0.423 | 0.209 |
| IL-15 | WC | –0.0005 (0.0095) | 0.955 | 0.478 |
| TNFα | WC | 0.0035 (0.0089) | 0.695 | 0.361 |
| sCD40L | WC | –0.0059 (0.0106) | 0.577 | 0.295 |
| Proinflammatory Chemokines | ||||
| Eotaxin-1 | WC | –0.0151 (0.0136) | 0.270 | 0.158 |
| Fractalkine | WC | –0.0059 (0.0140) | 0.674 | 0.339 |
| GRO | WC | 0.0099 (0.0139) | 0.476 | 0.237 |
| IL-8 | WC | –0.0077 (0.0104) | 0.459 | 0.235 |
| IP-10 | WC | 0.0285 (0.0118) | 0.0173 | 0.0183 |
| MCP-1 | WC | 0.0116 (0.0078) | 0.141 | 0.084 |
| MCP-3 | WC | –0.0003 (0.0085) | 0.971 | 0.496 |
| MDC | WC | 0.0001 (0.0126) | 0.996 | 0.491 |
| MIP-1β | WC | 0.0086 (0.0067) | 0.205 | 0.105 |
| RANTES | WC | –0.0012 (0.0093) | 0.898 | 0.454 |
| Anti-Inflammatory Hormones & Cytokines | ||||
| Adiponectin | WC | –0.0967 (0.0367) | 0.0093 | 0.0031 |
| IL-1RA | WC | 0.0162 (0.0080) | 0.0453 | 0.0193 |
| IL-4 | WC | –0.0050 (0.0122) | 0.682 | 0.350 |
| IL-10 | WC | –0.0001 (0.0110) | 0.992 | 0.491 |
| Growth Factors | ||||
| EGF | WC | –0.0140 (0.0127) | 0.272 | 0.140 |
| FGF-2 | WC | –0.0272 (0.0140) | 0.053 | 0.0323 |
No associations remained significant after Bonferroni multiple testing correction. Bonferroni threshold for significance: 0.05/16 = 0.003125. The effective number of independent immune biomarkers, determined by spectral decomposition (39), equaled 16. EGF, epidermal growth factor; FGF, fibroblast growth factor; GM-CSF, Granulocyte-macrophage colony-stimulating factor; GRO, growth related cytokine; hsCRP, high-sensitivity C-reactive protein; IP, inflammatory protein; MCP, Monocyte chemoattractant protein-1; MIP, macrophage inflammatory protein; RANTES, regulated upon activation, normal T-cell expressed and secreted; sCD40L, soluble cluster of differentiation 40 ligand; WC, waist circumference.
Empirical P values of the permutation test. β values are slopes of the regression models.
P values < 0.05 but greater than the Bonferroni threshold for significance.