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. 2022 Jan 28;239(3):795–806. doi: 10.1007/s00213-022-06069-w

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Effects of acute administration of WSE (50 mg/kg i.p.) on the expression of ethanol (2 g/kg i.p.)- (A) and morphine (5 mg/kg i.p.)- (B) elicited pERK-positive neurons in the AcbSh of adult male CD1 mice. Data are shown as mean + SEM of pERK-positive neurons/area. ^#indicates a significant difference (p < 0.05) vs pre-conditioning, same experimental group in Fig. 3A; ^##indicates a significant difference (p < 0.05) vs all groups in Fig. 3B