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. 2021 Nov 10;52(3):527–546. doi: 10.1007/s40279-021-01590-y

Table 5.

Metabolite species reported multiple times as negatively associated with CRF

Metabolite super classes Metabolite species Studies reporting negative associations with CRF
Lipids and lipid-like molecules CAR(3) propionylcarnitine [41, 45, 47]
CAR(6) hexanoylcarnitine [41, 45]
TAG(46:1), TAG(46:2), TAG(46:3), TAG(47:0), TAG(47:2), TAG(48:1), TAG(48:2), TAG(48:3), TAG(48:4), TAG(48:5), TAG(49:0), TAG(49:1), TAG(49:2), TAG(49:3), TAG(50:1), TAG(50:2), TAG(50:3), TAG(50:4), TAG(50:5), TAG(50:6), TAG(51:0), TAG(51:1), TAG(51:2), TAG(51:3), TAG(52:1), TAG(52:2), TAG(52:3), TAG(52:4), TAG(52:5), TAG(52:6), TAG(52:7), TAG(53:2), TAG(53:3), TAG(54:1), TAG(54:2), TAG(54:3), TAG(54:4), TAG(54:5), TAG(54:6), TAG(54:7), TAG(54:8), TAG(55:2), TAG(55:3), TAG(56:5) [41, 45]
γ-Tocopherol [39, 53]
Cer(18:1;2/16:0) [36, 41, 45]
Cer(18:1;2/18:0) [34, 36]
Cer(18:1;2/20:0) [34, 36]
HexCer(18:1;2/18:0) [36, 45]
SM(18:1;2/18:0) [41, 45]
SM(18:1;2/18:1) [36, 41, 45]
Glycocholic acid [41, 45]
Nucleosides, nucleotides, and analogs Pseudouridine [41, 51]
Organic acids and derivatives Alanine [41, 47]
Citrulline [45, 47]
Creatine [41, 45, 47]
Lysine [40, 41, 47]
Ornithine [41, 45, 47]
Isoleucine [41, 47]
Leucine [41, 47]
Thyroxine [41, 47]
Proline [41, 47]
Lactic acid [40, 41]
Pyruvic acid [41, 47]
Organic nitrogen compounds Carnitine [41, 45]
Organic oxygen compounds Gluconic acid [40, 45]

CAR carnitine, Cer ceramide, CRF cardiorespiratory fitness, HexCer hexosylceramide, SM sphingomyelin, TAG triacylglycerol