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. 2021 Oct 31;61(3):387–400. doi: 10.1007/s40262-021-01071-5
Inebilizumab is a humanized, immunoglobulin G1κ monoclonal antibody that binds to CD19, resulting in effective depletion of peripheral B cells.
The pharmacokinetics of inebilizumab were adequately described by a two-compartment model with parallel first-order and time-dependent nonlinear elimination pathways.
Common covariates had no clinically relevant impact on the pharmacokinetics of inebilizumab.