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. 2022 Mar 2;79(3):168. doi: 10.1007/s00018-022-04205-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Aβ levels are reduced in APP/lon mice knockout for meprin β. A Soluble-extracted brain fractions from 15-month-old APP/lon and APP/lon × Mep1b^−/− mice were analyzed by immunoblot for Aβ peptides species. Samples were on the same gel but are rearranged for better presentation. B Densitometric analysis of Aβ_1–42 levels show a decrease in soluble fractions (****p < 0.0001, t-test, n = 10). C ELISA analysis showed decreased levels of 1–40 (*p < 0.05, t-test, n = 8) and 1–42 (*p < 0.05, t-test, n = 8) in soluble fractions of APP/lon × Mep1b^−/− compared to APP/lon mice. D No differences were detected in insoluble brain fractions (n = 9–10). E A following ELISA approach revealed reduced levels of Aβ x–40 (p < 0.005, t-test, n = 7) and x–42 (p < 0.05, t-test, n = 4) in soluble brain fractions of APP/lon × Mep1b^−/− (F) No obvious differences were identified in total Aβ species x–40 and x–42 in insoluble brain fractions (n = 6)