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. 2022 Mar 2;12:2690. doi: 10.1038/s41598-022-06513-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Primary screen results by using cortical neurons of sporadic Alzheimer’s disease. Scatter plot graph of (a) Aβ40 (blue round), (b) Aβ42 (red round), (c) Aβ42/40 ratio (black round), and (d) cellular damage (black x-mark). Fold change compared with DMSO control was plotted after adding compounds at a concentration of 1 μM. Hit compounds were highlighted by yellow color with compound name. DMSO dimethyl sulfoxide (negative control), BSI β-secretase inhibitor (β-secretase inhibitor IV, positive control for Aβ40), GSM γ-secretase modulator (JNJ-40418677, positive control for Aβ42 and Aβ42/40 ratio). (e) Table showing coefficients of variation (CV%) of DMSO, negative control (left column), and standard deviation (S.D.) of whole screening for each analyte. (f) Hit selection criteria.