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. 2022 Mar 2;12:2690. doi: 10.1038/s41598-022-06513-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Mer-A2026A upregulated Aβ42/40 ratio at low concentration and reduced Aβ production at high concentration. (a) Structure of Mer-A2026A, (b) dose-dependent effect of Mer-A2026A on Aβ40 (blue line), Aβ42 (red line), Aβ42/40 ratio (black line), and cellular damage (dash line). Data represent mean ± SD (n = 3 per clone).