Skip to main content
. 2022 Mar 2;13:1116. doi: 10.1038/s41467-022-28750-6

Fig. 4. Genetic characteristics of the blaNDM-carrying, mcr-carrying, and/or tetX4-carrying plasmids identified in this study.

Fig. 4

a Circle map showing the structure of the blaNDM-carrying plasmid pXD33-05; b Circle map showing the structure of the mcr-carrying plasmid pXD33-06; c Circle map showing the structure of the tetX4-carrying plasmid pHB50-tetX4; arrows in purple, green, gray, orange, and blue refer to antimicrobial resistance genes, mobilization-associated genes (including insertion elements), hypothetical protein-encoding genes, functional protein-encoding genes, and type IV pilus formation-related genes, respectively; d Circle map showing sequence alignments of pXD33-05 and those plasmids with a backbone shared with other Enterobacteriaceae bacteria; circles from inside to outside indicate the GC content of pXD33-05 (circle 1), the GC skew of pXD33-05 (circle 2), pXD33-05 (circle 3), the E. coli plasmid pHNEC55 (GenBank accession no. KT879914; circle 4), the E. coli plasmid pHNHNC02 (GenBank accession no. MG197497; circle 5), and the K. pneumoniae plasmid pKPC-L388 (GenBank accession no. CP029225; circle 6); the plasmid backbone regions are highlighted in light green, while the multidrug resistance regions are highlighted in light red; nucleotide identities are shown with different colors below the maps; e Circle map showing the sequence alignments of pXD33-06 and those plasmids with a backbone shared with other Enterobacteriaceae bacteria; circles from inside to outside indicate the GC content of pXD33-06 (circle 1), the GC skew of pXD33-06 (circle 2), pXD33-06 (circle 3), the E. coli plasmid pWI2-mcr (GenBank accession no. LT838201; circle 4), the Salmonella plasmid pSH15G2169 (GenBank accession no. MH522417; circle 5), and the K. pneumoniae plasmid 16BU137_mcr-1.1 (GenBank accession no. MT316509; circle 6); nucleotide identities are shown with different colors below the map.