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. 2022 Mar 2;13(3):202. doi: 10.1038/s41419-022-04649-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Analysis of the differential genes (DEGs) between metformin-treated group (24 h) and control group (24 h) in GSE67342 dataset. b Heatmap and volcano map showing DEGs between CRC tissues and adjacent tissues in GSE15781 profile. c Comparison of the genes altered in GSE67342 (|log2FC | >2; p < 0.05) with GSE15781 dataset (|log2FC | >2; p < 0.05). d, e GEPIA online database analyzing the mRNA expression of INHBA in CRC tissues and normal colon tissues (d), as well as the expression of INHBA in CRC tissues from the different stages (e). f Kaplan–Meier curve showing the OS probability of CRC patients from the GEPIA database with low or high mRNA levels of INHBA (log-rank test). OS overall survival. g Expression of INHBA in various tumor tissues and their adjacent tissues. Red boxplot: tumor tissues; Bule boxplot: normal tissues; Purple boxplot: metastatic tissues. The data was gained from the TIMER database.