Table 2.

Association between AKI and mortality risk after multiple adjustments for confounding factors. Note: Models 1 to Model 3 follow an increasing complexity: Model 1: age, sex and clinical center; Model 2 = Model 1 + diabetes and chronic kidney disease; Model 3 = Model 2 + dyspnea, heart rate, respiratory rate, oxygen saturation and C-reactive protein (i.e. those pre-existing conditions and parameters at admission associated both with higher AKI and mortality risk).

	Entire population (n = 939; deaths = 89)		Only those with AKI onset before ICU and at least 48 h before death (n = 911; deaths = 68)
	R.R. (95% .I.)	P	R.R. (95% .I.)	P
Unadjusted	9.2 (6.3–13.6)	< 0.0001	7.1 (4.6–11.0)	< 0.0001
Model 1	6.6 (4.2–10.4)	< 0.0001	4.1 (2.4–6.9)	< 0.0001
Model 2	5.6 (3.5–8.8)	< 0.0001	3.4 (1.9–5.8)	< 0.0001
Model 3	3.7 (2.2–6.0)	< 0.0001	2.5 (1.4–4.6)	0.0025