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. 2022 Mar 2;13(3):199. doi: 10.1038/s41419-022-04647-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A IHC staining demonstrated high expressions of molecules involved in ATP-HIF-1α signaling in breast cancer tissues compared with paired paracarcinoma tissues. B IHC illustrated that HIF-1α level was associated with breast cancer TNM stage and grade. Data were calculated by Image Pro-Plus (IPP) (Media Cybernetics, Inc., Rockville, MD, USA). C Kaplan–Meier survival analysis (http://kmplot.com/analysis/) showed the negative correlations between survival time of breast cancer patients and expressions of HIF-1α. RFS relapse-free survival; OS overall survival; DMFS distant metastasis-free survival; PPS post-progression survival. D IHC showed that high expressions of HIF-1α is associated with recurrence after chemotherapy combination treatment. AC= Adriamycin + Cyclophosphamide, AT= Adriamycin + Taxotere, CAF= Cyclophosphamide + Adriamycin + Fluorouracil, FAC= Fluorouracil + Adriamycin + Cyclophosphamide. Error bars represent means ± SD from at least triplicates. Data are representative of at least three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001.