Fig. 8.

SOS1-IT1 is clinically relevant in EC and promotes EC cell growth. a, b The expression level of SOS1-IT1 in normal and tumor tissues of TCGA EC database. c–f The correlation analysis of SOS1-IT1 and clinicopathological parameters of EC, including the age, disease type, fustat and grade. g Kaplan–Meier analysis of SOS1-IT1 and the prognosis in EC patients. h, i The endometrial cancer cell line Ishikawa was knocked down with two different SOS1-IT1 shRNA (h), or transfected with SOS1-IT1 plasmid (i), and the expression level of SOS1-IT1 was detected by real-time PCR. j, k The cell growth was performed by WST-1 assays in SOS1-IT1 knocked down or overexpression in Ishikawa cells. ** P < 0.01, ***P < 0.001