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. 2022 Feb 17;13:826337. doi: 10.3389/fimmu.2022.826337

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Copyright © 2022 Fang, Sheng, Chen, Wang, Mao, Han, Liu, Wang, Gui, Zhang, Zhang, Li, Hu, Deng, Liu, Xu, Xu, Wang, Liu and Kong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Using data from the GTEx database, mRNA expression levels of CDCA4 in multiple organs of healthy persons; (B) From the data of CCLE database, CDCA4 expression levels are not only higher universally in diverse cancer cell lines, but also in tighter ranges when compared to the range of expression in normal tissues; (C) Taking TCGA data alone, CDCA4 expression differences between tumor and normal tissues for 20 cancers; (D) Combining the data from TCGA and GTEx, CDCA4 expression differences between tumor and normal tissues for 27 cancers. (*** represents p < 0.001).